JavaScript is not enabled!...Please enable javascript in your browser

جافا سكريبت غير ممكن! ... الرجاء تفعيل الجافا سكريبت في متصفحك.


Amyloidosis : Causes-Symptoms-Diagnosis-Treatment

 What is Amyloidosis?

Amyloidosis is once AN abnormal macromolecule referred to as amyloid builds up in your tissues and organs. once it will, it affects their form and the way they work. sickness could be a serious ill health which will cause grievous organ failure.

What is Amyloidosis?

Amyloidosis is a rare disease that affects about 2,500 people in the United States. The disease occurs when proteins within the body form deposits in organs and tissues and can damage the kidneys, heart lungs, liver, and other organs. There is no cure for amyloidosis. To the organ affected by amyloid deposition.

  1. Digestive system

Medical terms

  • Amyloidosis is a rare disorder that occurs when abnormal proteins called amyloids build up in the body's tissues and organs. The proteins can cause organ and tissue damage, which can lead to serious complications. Amyloid proteins are produced from the breakdown of certain proteins in your body, including those from your immune system. Amyloidosis can affect any part of your body and can cause a variety of symptoms, depending on which organs or tissues are involved.

  • Amyloidosis is a rare, systemic disease caused by the abnormal deposition of a protein known as amyloid in tissues and organs. It can be caused by a number of different underlying disorders, including but not limited to, chronic infections, malignancies, and inflammatory conditions. The prognosis for the disease depends on the underlying cause. Treatment for amyloidosis typically involves a combination of medication to manage the symptoms, lifestyle changes, and in some cases, surgery.

  • Treatments might embrace therapy almost like that accustomed to combat cancer. Your doctor might counsel medications to cut back amyloid production and to regulate symptoms. Some individuals might have the benefit of organ or vegetative cell transplants.

  • Amyloidosis is a rare disease in which abnormal protein deposits develop in the organs and tissues of the body Amyloid also can accumulate in bone marrow lymph nodes liver and spleen There are four types of amyloidosis based on the specific protein that's deposited: light chain amyloidosis (type 1) serum amyloid A amyloidosis (type 2) transthyretin-related hereditary amyloidosis (types 3 and 4) and AL (adult) type amyloidosis

  • Treatment Amyloidosis is a rare disease where abnormal protein deposits in organs tissues and blood vessels cause inflammation (swelling) and interfere with organ function Amyloidosis can occur throughout the body as either localized or systemic amyloidosis Localized amyloidosis occurs when there’s excess deposition of amyloid proteins in one area of the body such as an organ or tissue Systemic amyloidosis is characterized by accumulation of the insoluble beta-amyloid protein throughout the entire body The severity of clinical symptoms depends on which areas of your body are affected by this buildup It.

Symptoms Amyloidosis

You may not experience signs and symptoms of sickness till the condition is advanced. Once signs and symptoms are evident, they rely on that of your organs.

Signs and symptoms of sickness could include:

  • Swelling of your ankles and legs

  • Severe fatigue and weakness

  • Shortness of breath with minimal exertion

  • Unable to lie flat in bed due to shortness of breath

  • Numbness, tingling or pain in your hands or feet, especially pain in your wrist (carpal tunnel syndrome)

  • Diarrhea, possibly with blood, or constipation

  • Unintentional weight loss of more than 10 pounds (4.5 kilograms)

  • An enlarged tongue, which sometimes looks rippled around its edge

  • Skin changes, such as thickening or easy bruising, and purplish patches around the eyes

  • An irregular heartbeat

  • Difficulty swallowing

When to see a doctor

See your doctor if you persistently experience any of the signs or symptoms associated with amyloidosis.

Causes Amyloidosis

There are many alternative forms of sickness. Some varieties are unit hereditary. Others are units caused by outside factors, like inflammatory diseases or semipermanent qualitative analysis. Many sorts have an effect on multiple organs, whereas others have an effect on just one part of the body.

Subtypes of sickness include:

  • AL amyloidosis (immunoglobulin light chain amyloidosis). The most common type of amyloidosis in developed countries, AL amyloidosis is also called primary amyloidosis. It usually affects the heart, kidneys, liver and nerves.

  • AA amyloidosis. Also called secondary unwellness, this selection is sometimes triggered by Associate in Nursing disease, like atrophic arthritis. Improved treatments for severe inflammatory conditions have resulted in an exceedingly sharp decline within the variety of cases of AA unwellness in developed countries. It most ordinarily affects the kidneys, liver and spleen. 

  • Hereditary amyloidosis (familial amyloidosis). This inherited disorder often affects the nerves, heart and kidneys. It most commonly happens when a protein made by your liver is abnormal. This protein is called transthyretin (TTR).

  • Wild-type amyloidosis. This form of unwellness happens once the TTR macromolecule created by the liver is traditional, however it produces amyloid for unknown reasons. Once called doddering general unwellness, wild-type unwellness tends to have an effect on men over age seventy and usually targets the guts. It can even cause carpal tunnel syndrome. 

  • Localized amyloidosis. This type of amyloidosis often has a better prognosis than the varieties that affect multiple organ systems. Typical sites for localized amyloidosis include the bladder, skin, throat or lungs. Correct diagnosis is important so that treatments that affect the entire body can be avoided.

Risk factors Amyloidosis

Factors that increase your risk of amyloidosis include:

  • Age. Most people diagnosed with amyloidosis are between ages 60 and 70, although earlier onset occurs.

  • Sex. Amyloidosis occurs more commonly in men.

  • Other diseases. Having a chronic infectious or inflammatory disease increases your risk of AA amyloidosis.

  • Family history. Some types of amyloidosis are hereditary.

  • Kidney dialysis. Dialysis can't always remove large proteins from the blood. If you're on dialysis, abnormal proteins can build up in your blood and eventually be deposited in tissue. This condition is less common with more modern dialysis techniques.

  • Race. People of African descent appear to be at higher risk of carrying a genetic mutation associated with a type of amyloidosis that can harm the heart.

Complications Amyloidosis

The potential complications of amyloidosis depend on which organs the amyloid deposits affect. Amyloidosis can seriously damage your:

  • Heart. Amyloid reduces your heart's ability to fill with blood between heartbeats. Less blood is pumped up with every beat, and you will expertise shortness of breath. If malady affects your heart's electrical system, your cardiac rhythm is also disturbed. Amyloid-related heart issues will become grievous. 

  • Kidneys. Amyloid can harm the kidneys' filtering system, causing protein to leak from your blood into your urine. The kidneys' ability to remove waste products from your body is lowered, which may eventually lead to kidney failure and the need for dialysis.

  • Nervous system. You may experience pain, symptoms or tingling of your fingers or symptom, lack of feeling or a burning sensation in your toes or the soles of your feet. If amyloid affects the nerves that manage your internal organs, you will experience periods of alternating constipation and diarrhea. If it affects the nerves that manage vital signs, you will feel faint when standing up too quickly. 

What is the average life expectancy for a person with amyloidosis?

The life expectancy of a person with amyloidosis varies greatly from patient to patient. The disease is generally divided into three groups: local (systemic) amyloidosis where the only organs affected are the kidneys and heart; An intermediate in which both systemic and organ-specific forms of the disease are present simultaneously; Generalized amyloidosis that affects all parts of the body.

Can you live a normal life with amyloidosis?

Amyloidosis describes a group of diseases that cause abnormal proteins called amyloids to build up in various parts of the body. These deposits eventually form lumps or lumps. Amyloidosis affects various organs and systems throughout the body, causing a wide range of symptoms including fatigue, weight loss, and abdominal pain.

What are the warning signs of amyloidosis?

Amyloidosis is a rare disorder in which certain abnormal proteins build up in body tissues and fluids, eventually causing damage to organs and impairing normal functioning. Proteins that are then deposited in different parts of the body The most common form is primary systemic amyloidosis, which occurs when a protein produced by the liver accumulates in tissues and organs throughout the body rather than being eliminated from the bloodstream, also called "AL (essential).

Is amyloidosis an incurable disease?

Amyloidosis is an uncommon blood disorder that occurs when bundles of the abnormal protein (amyloid) build up in organs and tissues and eventually damage vital organs including the kidneys, heart and digestive system. For Dr. David Nessel, medical director of the Comprehensive Center for Hematology and Oncology at Houston Methodist Hospital in Texas, there are three types of amyloidosis: primary or acquired (AA) amyloidosis and familial Mediterranean fever (FMF).

What are the stages of amyloidosis?

Amyloidosis is a disease characterized by the abnormal accumulation of substances called amyloid proteins in tissues and organs. There are three main types of amyloidosis: primary, secondary, and hereditary. The three types differ greatly from each other individually as well as in groups. Primary amyloidosis occurs when an organ's tissues produce too much transretinal (TTR) protein. TTR is naturally present in the blood where it helps transport vitamin A to certain organs such as the heart and kidneys.

How quickly does amyloidosis progress?

Amyloidosis is a rare, chronic disease of the body's organs. People with this condition usually have abnormal proteins in their blood or urine. Over time, these abnormal proteins build up in your organs and damage tissues. Health problems There is currently no cure for amyloidosis, but treatment can help control symptoms and prevent further complications from organ failure. Most people diagnosed with amyloidosis live at least five years after diagnosis. If they do not receive treatment.

Diagnosis Amyloidosis

To see if you have got an illness, your doctor can probably order tests. A excreta takes a look at and a biopsy is also followed by one or additional imaging procedures to require a glance at your body’s internal organs, like AN sonogram , nuclear heart take a look at or liver ultrasound . A genetic take a look at is also necessary to envision if you have got the familial style of illness.

You might endure a diagnostic assay, wherever the doctor takes atiny low sample of your bone marrow or another organ to look at beneath the magnifier.

Amyloidosis is usually unmarked as a result of the signs and symptoms will mimic those of more-common diseases.

Early identification will facilitate stopping any organ harm. Precise identification is vital as a result of treatment varies greatly, counting on your specific condition.

Laboratory tests

Your blood and excretory product could also be analyzed for abnormal supermolecules that may indicate illness. counting on your signs and symptoms, you will even have thyroid and liver operations.

  1. Blood analysis

  2. Blood count

  3. Blood typing


A tissue sample is also taken and checked for signs of illness. The diagnostic test is also taken from the fat beneath the skin on your abdomen (fat aspirate), bone marrow, or AN affected organ — like your liver or excretory organ. Specialized testing of the tissue will facilitate verification of the sort of amyloid deposit.

Imaging tests

Images of the organs affected by amyloidosis can help establish the extent of your disease. Tests may include:

  • Echocardiogram. This technology uses sound waves to form moving pictures that may show however well your heart is functioning. It may also show heart injury that may be specific to explicit styles of malady. 

  • Magnetic resonance imaging (MRI). MRI uses radio waves and a robust field of force to form careful pictures of organs and tissues in your body. These may be wont to assess the structure and performance of your heart. 

  • Nuclear imaging. In this test, tiny amounts of radioactive material (tracers) are injected into a vein. This can reveal early heart damage caused by certain types of amyloidosis. It can also help distinguish between different types of amyloidosis, which can guide treatment decisions.

Treatment Amyloidosis

There's no cure for malady. However, treatment will facilitate managing signs and symptoms and limit additional production of amyloid supermolecules. If the malady has been triggered by another condition, like autoimmune disorder or T.B., treating the underlying condition may be useful.


  • Chemotherapy. Many of the same types of medicines used to treat some forms of cancer are used in AL amyloidosis to stop the growth of abnormal cells that produce the protein leading to formation of amyloid.

  • Heart medications. If your heart is affected, your doctor could recommend blood thinners to cut back the chance of clots and medications to manage your rate. You'll additionally have to be compelled to prohibit your salt intake and take medicine that increases micturition, which may scale back the strain on your heart and kidneys. 

  • Targeted therapies. For certain sorts of sickness, medicine like patisiran (Onpattro) and inotersen (Tagxedo) will interfere with the commands sent by faulty genes that make amyloid. Different medicines, like tafamidis (Vidamax, Vyndaqel) and NSAID, will stabilize bits of macromolecule within the blood and stop them from being remodeled into amyloid deposits. 

Surgical and other procedures

  • Autologous blood stem cell transplant. This procedure involves collecting your own stem cells from your blood through a vein and storing them for a brief time whereas you have got high-dose therapy. The stem cells then came back to your body via a vein. This treatment is most acceptable for individuals whose malady is not advanced and whose heart is not greatly affected. 

  • Dialysis. If your kidneys have been damaged by amyloidosis, you may need to start dialysis. This procedure uses a machine to filter wastes, salts and fluid from your blood on a regular schedule.

  • Organ transplant. Your doctor might suggest surgery to replace your heart or kidneys if amyloid deposits have severely damaged those organs. Some types of amyloid are formed in the liver, so a liver transplant could halt that production.

Preparing for your appointment

You may be referred to a doctor who specializes in blood disorders (hematologist).

What you can do

  • Write down your symptoms, including any that may seem unrelated to the reason why you scheduled the appointment.

  • Make a list of all your medications, vitamins and supplements.

  • Write down your key medical information, including other conditions.

  • Write down key personal information, including any recent changes or stressors in your life.

  • Write down questions to ask your doctor.

  • Ask a relative or friend to accompany you, to help you remember what the doctor says.

Questions to ask your doctor

  • What's the most likely cause of my symptoms?

  • What type of amyloidosis do I have?

  • What organs are affected?

  • What stage is my disease?

  • What kinds of tests do I need?

  • What kind of treatments do I need?

  • Am I at risk of long-term complications?

  • What types of side effects can I expect from treatment?

  • Do I need to follow any dietary or activity restrictions?

  • I have another health condition. How can I best manage them together?

In addition to the questions that you've prepared to ask your doctor, don't hesitate to ask other questions during your appointment.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may provide time to go over points you want to spend more time on. You may be asked:

  • When did you first begin experiencing symptoms? How severe are they, and are they continuous or occasional?

  • Does anything seem to make your symptoms better or worse?

  • How is your appetite? Have you recently lost weight without trying?

  • Have you experienced any leg swelling?

  • Have you experienced shortness of breath?

  • Are you able to work and perform normal daily tasks? Are you often tired?

  • Have you noticed that you bruise easily?

  • Has anyone in your family ever been diagnosed with amyloidosis?

General summary

  1. Amyloidosis is a condition that can affect many different organs in the body, and causes deposits of protein to form inside these organs. Each type of amyloidosis has its own treatment program.

  2. Amyloidosis is a rare disease that occurs when abnormal proteins, referred to as amyloid, accumulate within the body's organs and tissues. Amyloid proteins are produced by several types of cells in the body, and are normally broken down and removed. In cases of amyloidosis, however, the proteins accumulate due to an abnormal production or an underlying medical condition that affects the body’s ability to break them down and remove them. As a result, amyloid deposits form in various organs, resulting in organ dysfunction or failure.

  3. Amyloidosis is a rare and complex condition caused by a build-up of abnormal proteins called amyloid in the body's organs and tissues. It can affect any organ or tissue and the severity of symptoms can vary widely. Common symptoms include difficulty breathing, fatigue, swelling, and confusion. There is no single test to diagnose amyloidosis, and diagnosis often requires multiple tests and scans.

  4. Amyloidosis is a rare, potentially fatal, disease which is caused when the body produces an abnormal protein known as amyloid. Amyloid proteins can accumulate in various organs and tissues in the body, affecting their normal functioning. The exact cause of amyloidosis is still unknown, but it has been linked to certain genetic conditions as well as environmental factors. In some cases, amyloidosis can be managed with medication and lifestyle changes, while in other cases, it can be life threatening and require aggressive treatment.

Amyloidosis : Causes-Symptoms-Diagnosis-Treatment

usa-good- clinic

    No comments
    Post a Comment