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Esthesioneuroblastoma(ENB): Causes, Types, Symptoms, Diagnosis ,Treatment , Risk factors , Complications , Prevention

 What Is Tumor Esthesioneuroblastoma(ENB)?

Esthesioneuroblastoma (ENB) is a form of rare tumor determined inside the nose. It is likewise referred to as olfactory neuroblastoma because it grows in nerve cells within the nose and might affect your experience of scent. An esthesioneuroblastoma generally begins inside the top part of the nasal cavity, that is the open space in the back of and above the nose. It is considered a skull base tumor. 


It is found in each person, ladies and men — at any age. However, it's far distinctly uncommon and best makes up about 3 to 5 percent of all tumors that occur in the nose.

Esthesioneuroblastoma (ENB) is also referred to as Olfactory Neuroblastoma. It is an unusual malignant tumor of the upper nasal cavity and anterior skull base. It is thought to stand up from the olfactory neuroepithelium that strains the cribriform plate, advanced component of the nasal septum, middle turbinate, and advanced turbinate. The olfactory neuroepithelium incorporates specialized receptor cells that mediate the feel of smell. ENB began to be described through Berger and Luc in 1924, and is now thought to symbolize a few percent of all malignant nasal tumors. ENB happens over a large age variety and has a bimodal age distribution in the second and fifth decade, with maximum sufferers in their fifties and sixties. It has a propensity to metastasize to neck lymph nodes, and plenty less normally to remote regions within the body. There are not any recognized particular reasons or threat elements for growing this tumor.

What Is Tumor Esthesioneuroblastoma(ENB)

Explanation of medical terms and concept Esthesioneuroblastoma(ENB)

Esthesioneuroblastoma is a rare cancer that starts in the upper part of the nose.

The area where esthesioneuroblastoma begins is separated from the brain by a bone that has small openings that allow the nerve cells that control smell to pass through. Esthesioneuroblastoma is also called olfactory neuroblastoma.

Esthesioneuroblastoma is a tumor that can occur at any age in adults, and it generally begins as a tumor in the nasal cavity. People with esthesioneuroblastoma may lose their sense of smell, have frequent nosebleeds, and experience difficulty breathing through their mouth. When the tumor grows, the nostrils will become congested.

Esthesioneuroblastoma can also spread to the lymph nodes in the neck and the parotid glands. In more advanced cases, esthesioneuroblastoma can spread to other parts of the brain and other parts of the body.

Treatment for Esthesioneuroblastoma usually includes surgery and radiation and chemotherapy.

Esthesioneuroblastoma, or olfactory neuroblastoma, is an unprecedented malignant neoplasm of the sinonasal tract originating from the olfactory neuroepithelium with neuroblastic differentiation. It most often gives within the advanced nasal hollow space. It is a regionally competitive neoplasm and metastasizes through both hematogenous and lymphatic routes. This interest critiques the assessment, analysis, and control of esthesioneuroblastoma and the function of team-based totally interprofessional care for affected sufferers.

Is esthesioneuroblastoma malignant?

Esthesioneuroblastoma is a rare type of cancer that affects sensory nerves These types of cancers are also called "neuroblastomas." The exact cause of esthesioneuroblastoma is not known but it is thought to be caused by the abnormal development of cells in the orbit These tumors affect only about 1 in every one million people per year.

How common is esthesioneuroblastoma?

Esthesioneuroblastoma also known as olfactory neuroblastoma is a rare type of cancer that affects the tissues surrounding the olfactory nerves The olfactory nerves are responsible for the sense of smell so esthesioneuroblastoma can cause severe damage to one's sense of taste and smell Although esthesioneuroblastoma is a rare form of cancer it occurs most often in people between the ages of 20 and 40. About 62 percent of all cases are diagnosed in people between the ages of 20 and 34. This type of cancer accounts for about 0.1 percent of all cancers diagnosed each year.

Symptoms Esthesioneuroblastoma(ENB)

The most not unusual symptoms encompass nasal obstruction (issue breathing through the nostril) or nose bleeds. These signs begin regularly and are fallacious for different, extra commonplace reasons.

This sort of tumor is usually gradual-growing. As a result, 83% of patients with esthesioneuroblastoma have already got a tumor extending past the nose (into the mind or different areas of the frame) at the time of prognosis.

Signs that the tumor has spread may also include lack of scent, imaginative and prescient loss, eye pain or tearing, ear pain and intense complications.

Esthesioneuroblastoma symptoms include:

  • Losing the sense of smell

  • Frequent nosebleeds

  • Difficulty breathing through the nose

Cancer can cause pain in the eyes, ears, and head.

When to see a doctor

If you have any persistent signs or symptoms that concern you, make an appointment with your doctor.

Causes Esthesioneuroblastoma(ENB)

No unique reason for this tumor has been recognized. It is an incredibly uncommon tumor, accounting for less than 5 percent of tumors.

The cause of esthesioneuroblastoma has not been found, but it is likely due to a genetic mutation that allows cancer cells to grow uncontrollably. Cancer generally begins with abnormal cells that ignore normal signals to stop growing. A tumor forms when abnormal cells accumulate.


Some complications of esthesioneuroblastoma may include:

  • Cancer can grow and invade nearby structures.If advanced esthesioneuroblastoma (a cancer) grows large enough, it can invade nearby structures, such as the eyes and brain. If this happens, complications can occur.

  • Spread of the cancer (metastasis).Esthesioneuroblastoma may spread (metastasize) to other parts of the body, such as the lymph nodes, bone marrow, lungs, liver, and skin.

  • Loss of the sense of smell.The tumor can block the nasal passage, which can cause the flow of air through the nose to be blocked.

  • Complications from surgery.These complications can include spinal fluid leakage, vision problems, and an abscess.

Diagnosis Esthesioneuroblastoma(ENB)

A thorough history and a complete head and neck exam are performed first of all. Particular interest should be dedicated to the neck examination thinking about a significant percentage of sufferers (five-20%) have neck metastases at presentation. Nasal endoscopy is beneficial for comparing tumor place, characteristics and volume, in addition to for obtaining a biopsy.


Computed Tomography (CT) and Magnetic Resonance (MR) imaging are frequently complementary in characterizing the tumor and extension into surrounding systems, in particular the orbit and the brain. High-decision CT stays the preliminary look of choice. It presents superior bony definition and permits evaluation of the integrity of bony systems surrounding the tumor, inclusive of the orbit, skull base, septum, and palate. However, all sufferers with the confirmed or suspected diagnosis of ENB have to have both CT and MR imaging with exceptions most effective making use of very small and localized tumors. The principal value of MRI lies in its capability to outline the extent of the lesion and the involvement of surrounding systems, specifically the orbit, cranium base, dura, and brain parenchyma. It additionally allows differentiate among tumor and adjacent inflammatory modifications. This statistics is vital for proper preoperative surgical making plans.


Due to the tremendously excessive fee of neck involvement at presentation, a CT neck with intravenous assessment is automatically acquired to evaluate for occult metastasis. Metastatic workup also includes chest and abdomen CT, as well as liver characteristic checks. Alternatively a Positron Emission Tomography (PET) experiment can be received to evaluate for local and distant metastases.

A diagnosis of an esthesioneuroblastoma may involve:

  • Physical examination.Doctors use careful history, examination, and tests to understand the tumor's extent and make a diagnosis.

  • To see with a tiny camera in your nose.During an endoscopic examination, a thin, flexible tube is inserted through your nose. The tube is attached to a camera that allows doctors to see the extent of the tumor in the back of your nose (nasopharynx) and in the sinus area of your nasal cavity.

  • Imaging tests.MRI and PET scans help to determine the location and size of your esthesioneuroblastoma. This information can also help to determine if the tumor has spread.

  • Removing a sample of tissue for testing.A biopsy is a procedure to remove a small sample of tumor tissue for examination. This can be done by using special instruments that are inserted through your nose into the tumor. It may be done in a doctor's office.

  • Testing a tissue sample in a lab. It is necessary to accurately test and analyze the biopsy sample in order to distinguish esthesioneuroblastoma from other tumors. It is difficult to diagnose esthesioneuroblastoma because it is a rare tumor and may have a similar appearance to other cancers that occur in the head, neck area. Tumors can be found in different areas of the body, including the nose and mouth. Pathological analysis determines the aggressiveness of the tumor.

Treatment Esthesioneuroblastoma(ENB)

The remedy of ENB requires a multi-disciplinary team including an Otorhinolaryngologist-Head & Neck health care provider, a neurosurgeon, a radiation oncologist, and a clinical oncologist. Other experts, such as an ophthalmologist, may additionally emerge as involved as wanted. At TSBI, we provide information inside the minimally-invasive and multidisciplinary management of all skull base tumors, along with ENB.


Treatment relies upon the neighborhood tumor level and whether or no longer there's local or distant metastatic disease. Surgery on my own is great reserved for sufferers with small tumors placed inside the sinonasal hollow space without involvement of the cranium base or orbit. For more superior tumors, the maximum success remedy includes surgical operation and radiation therapy with maximum establishments favoring delivery of postoperative, as opposed to preoperative, radiotherapy. At TSBI, large and cumbersome tumors (T3 and T4) are dealt with with preoperative chemotherapy and radiotherapy followed with the aid of surgery. This allows for a doubtlessly much less invasive and less morbid surgical resection.


Although early reviews on chemotherapy in ENB centered on sufferers with recurrent or metastatic sickness, adjuvant chemotherapy is now typically employed for sufferers with advanced nearby and regional disease.


Treatment for ENB changed dramatically with the introduction of the blended transcranial and transfacial technique for tumors of the paranasal sinuses concerning the anterior skull base.

Cancer treatment for Esthesioneuroblastoma usually includes an operation to remove the cancer. Other options include radiation with high-energy beams and chemotherapy using powerful drugs.


There are different surgical techniques for tumors, depending on their location, and they may include procedures done by different people.

  • Removing the nasal portion of the tumor. This type of surgery is normally done using an endoscope. The surgeon uses a long, thin tube to look inside the nose and see if there is cancer. They use special tools to remove the cancer and the area around it. Cover the tissue around the leaf.

  • To access the tumor, you need to open up the skull.A craniotomy is a procedure to remove a small amount of the skull in order to remove a tumor and separate it from the brain.

Treating Esthesioneuroblastoma usually requires the expertise of multiple specialists, such as neurosurgeons, head and neck surgeons, radiation oncologists, and medical oncologists.

Radiation therapy

Radiation therapy uses high-energy beams to kill cancer cells. People with esthesioneuroblastoma often undergo radiation therapy after surgery to make sure any microscopic cancer cells are eliminated.

Radiation therapy can be used either alone or in combination with chemotherapy if surgery is not an option because of other health concerns or if the cancer is too advanced to be removed through surgery.


Cancer chemotherapy uses drugs to kill cancer cells. After surgery, people with esthesioneuroblastoma may receive radiation therapy to kill any cancer cells that may remain.

Alternative medicine

There is no medical cure for esthesioneuroblastoma, but complementary and alternative medicine (CAM) therapies may help you manage side effects of treatment. When used in combination with your doctor's care, CAM may be able to provide relief.

Some cancer treatments may include therapies that are helpful. These therapies may include:

  • Acupuncture

  • Aromatherapy

  • Hypnosis

  • Massage

  • Music therapy

  • Relaxation techniques

  • Tai chi

  • Yoga

Coping and support

A diagnosis of an esthesioneuroblastoma can be overwhelming. You may feel scared and worried about your future, when you're asked to make important decisions about your treatment.

Everyone responds to cancer in his or her own way. Until you find what helps you, it might be helpful to:

  • Be knowledgeable about your cancer so you can make intelligent decisions about your care.If you want to learn more about your cancer, your doctor can provide you with details about the type and grade of your esthesioneuroblastoma. Ask for sources of up-to-date information on your treatment options.
    Knowing more about your cancer and its treatment options may help you feel more confident when making decisions about care.

  • Talking with other cancer survivors.Talking to others who are going through the same thing can be helpful and encouraging. You can reach out to the American Cancer Society or National Cancer Institute to find out about support groups in your area and online.

  • Talk to someone about your feelings.Talk to someone who will listen attentively or find a friend or family member who can provide support. Ask your doctor for a referral to someone who can help with cancer recovery.

  • Keep your friends and family close.You will need friends and family to support you during your cancer treatment.
    When you tell other people about your esthesioneuroblastoma diagnosis, you will likely receive many offers of help. Make sure to think about things you may need assistance with, such as someone to talk to if you're feeling down or being helped with meal preparations.

Preparing for your appointment

If you have any signs or symptoms that make you worried, see your doctor. You might be referred to an ear, nose and throat specialist.

Here are some things to know in order to prepare for your appointment.

What you can do

  • Make sure you're aware of any pre-appointment restrictions.Make sure to ask if there are any preparations you need to make before the appointment, such as restricting your diet.

  • Write down any symptoms you are experiencing so that you can find a doctor or health professional to help you.Make sure to bring any materials you think may be helpful for your appointment. This includes anything unrelated to the reason for which you scheduled the appointment.

  • Write down key personal information,It is best to take this test if you have not had any major stresses or recent life changes.

  • Make a list of all medications, vitamins or supplements you are taking.

  • Take a family member or friend along.

  • Write down questions to ask your doctor.

You will have a limited time with your doctor, so it is helpful to prepare a list of questions. Make sure to ask the most important questions first, in case time runs out. Some basic questions to ask your doctor about esthesioneuroblastoma might include:

  • What could be causing my symptoms or condition?

  • What are some other possible causes for my symptoms or condition?

  • What kinds of tests do I need?

  • What is the likelihood of my condition being temporary or chronic?

  • What is the best course of action?

  • What are some other ways to do what you're suggesting?

  • I have other health conditions. How can they be best managed together?

  • Do I need to follow any specific guidelines?

  • Do I need to see a specialist? What will that cost and is my insurance likely to cover it?

  • Can I take any brochures or other printed material with me? What websites do you think I should visit?

  • What will determine whether I should have a follow-up visit?

If you have any questions about your doctor's visit, don't be afraid to ask them. And if you don't understand something, don't hesitate to ask.

What to expect from your doctor

Your doctor is likely to ask you several questions such as: -What symptoms are you experiencing? -What kind of tests do you want to do? -How severe is the condition?

  • When did your symptoms begin?

  • Has your condition been present for a long time or does it occur occasionally?

  • How severe are your symptoms?

  • What might make your symptoms better?

  • What if anything seems to make my symptoms worse?

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Esthesioneuroblastoma(ENB): Causes, Types, Symptoms, Diagnosis ,Treatment , Risk factors  , Complications , Prevention

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