Phenolsulfonphthalein Test : Diagnosis


 What Is Phenolsulfonphthalein Test?

Phenolsulfonphthalein check, additionally known as Psp Test, scientific manner for the estimation of universal blood go with the flow via the kidney; the check is used only infrequently now. A specific dose of the PSP dye is injected intravenously, and its recovery inside the urine is measured at successive 15-, 30-, 60-, and one hundred twenty-minute periods. The kidney secretes 80 percent of the PSP dye, the liver the ultimate 20 percent. The restoration price at 15 mins after injection (generally approximately 25–35 percent) is the most huge diagnostically, because even a broken kidney may be capable of disposing of the PSP dye from a move given a longer time to accomplish that. PSP excretion is reduced in most continual kidney diseases and may be elevated in some liver issues.

Phenolsulfonphthalein is used as a check to assist diagnose issues or sickness of the kidneys. This test determines how well your kidneys are operating.

Phenolsulfonphthalein passes out of the body almost absolutely in the urine. Measuring the amount of phenolsulfonphthalein in the urine can assist the physician determine if the kidneys are running nicely.

How the check is completed: After you've emptied your bladder, phenolsulfonphthalein may be given by injection. Then you will be requested to drain your bladder right into a field one or extra times after the medication is given. The amount of this medicine in your urine could be measured. Then the consequences of the check could be studied. The way the phenolsulfonphthalein takes a look at is completed may be one of a kind for one-of-a-kind sufferers. Some sufferers might also have the phenolsulfonphthalein injected into a vein, others, into a muscle.

It could be very essential that you empty the bladder absolutely and accumulate all the urine whilst you are requested to do so. If any urine is left in the back of or lost, it's going to change the results of the take a look at.

Phenolsulfonphthalein is to be used only beneath the supervision of a physician.

Many other indicators share a similar structure to phenol red, including:

  • Bromothymol blue.

  • Thymol blue.

  • Thymolphthalein.

  • Bromocresol purple.

  • Phenolphthalein.

Before using the phenolsulfonphthalein test

In deciding to use a diagnostic take a look at, any dangers of the test must be weighed against the coolest it's going to do. This is a selection you and your health practitioner will make. Also, different things can also affect test consequences. For this check, the following have to be taken into consideration:


Tell your medical doctor when you have ever had any uncommon or allergy to this medication or some other drug treatments. Also inform your health care professional when you have any other sorts of allergic reactions, along with ingredients, dyes, preservatives, or animals. For non-prescription merchandise, examine the label or bundle components carefully.


Although there's no precise statistics evaluating use of phenolsulfonphthalein in youngsters with use in other age corporations, phenolsulfonphthalein is not anticipated to cause one-of-a-kind side consequences or issues in kids than it does in adults.


Many drugs have now not been studied particularly in older human beings. Therefore, it is possible to not be recognized whether they work precisely the identical manner they do in more youthful adults. Although there's no specific information evaluating use of phenolsulfonphthalein in the elderly with use in different age businesses, this medicinal drug is not anticipated to cause distinct side effects or problems in older humans than it does in younger adults.

Drug Interactions

Although certain drug treatments should no longer be used collectively at all, in different instances  unique drugs may be used together even if an interaction would possibly occur. In those instances, your physician might also need to trade the dose, or different precautions may be important. Tell your healthcare professional if you are taking some other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain drugs should now not be used at or around the time of consuming food or eating sure forms of meals considering that interactions can also occur. Using alcohol or tobacco with certain medicines can also motive interactions to occur. Discuss with your healthcare professional using your medication with food, alcohol, or tobacco.

Other Medical Problems Phenolsulfonphthalein Test

The presence of other medical issues can also have an effect on the usage of this diagnostic. Take a look at. Make sure you inform your doctor when you have any other clinical issues, specifically:

  • Gout or

  • Liver disease or

  • Multiple myeloma (a type of most cancers)—These conditions can also affect how fast the frame receives rid of the phenolsulfonphthalein

  • Heart or blood vessel disease or

  • Kidney disorder (intense)—Patients with those situations are at greater chance of turning into unwell due to the massive quantity of drinks that need to be taken for this test

Uses a phenolsulfonphthalein test

The uses of PSP testing are as follows:

  • Phenolsulfonphthalein pH indicator is typically used as an indicator in labs, for the duration of titrations to determine the end-points.

  • It is commonly used as an indicator in cell cultures.

  • Used in-home swimming pool test kits.

  • Used in phenolsulfonphthalein tests for examining the general blood go with the flow through the kidney.

  • It has a position as a two-color indicator, an acid-base indicator, and a diagnostic agent.

Risks + Side Effects

Phenolsulfonphthalein is poisonous and can cause sensitization through pores and skin touch; inflammation to the eyes, respiration device, and pores and skin. Accidental ingestion of phenol purple can also damage your fitness. Limited evidence exists, declaring that the substance may also cause irreversible but non-lethal mutagenic effects, following a single exposure.

Along with its needed effects, a medicinal drug may cause some undesirable results. Although this medication generally does no longer cause any side outcomes, inform your health care professional immediately if you note wheezing or skin rash or itching shortly after it's miles given.

Other side consequences no longer indexed may additionally arise in some patients. If you word some other consequences, check along with your healthcare professional.

Phenolsulfonphthalein Test Procedures

  • You might be requested to empty your bladder.

  • You could be given phenolsulfonphthalein dye by way of injection, in your vein or muscle mass.

  • Again, you may be asked to empty your bladder into approximately 3 boxes, at intervals of 15, 30, and 60 mins, after the administration of the phenolsulfonphthalein dye.

  • The amount of the medicine (PSP) on your urine could be measured by the usage of a colorimeter.

  • After the whole thing, the results of the check might be studied cautiously.


Your health practitioner will talk about the end result of the PSP check with you, after cautiously studying it. Typically, the kidney secretes 80% of the phenolsulfonphthalein dye, at the same time as the liver secretes the final 20%. 

The recuperation cost at 15 minutes after injection is generally about 25─35%, and it's miles the maximum tremendous diagnostic fee, due to the fact that a broken kidney can be able to put off the phenolsulfonphthalein dye from circulate, supply an extended time to do so. 

PSP excretion is decreased in numerous continual kidney illnesses and can be improved in certain liver disorders.

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