The comprehensive guide : Acute flaccid myelitis

Acute flaccid myelitis: Question and Answer


Acute Flaccid Myelitis (AFM) is a rare but debilitating neurological condition that has garnered increasing attention in recent years. Characterized by sudden muscle weakness and paralysis, AFM primarily affects children and has left both medical professionals and the public with numerous questions. In this comprehensive article, we will explore the nature of AFM, its prevalence, the medical specialists involved in its treatment, the current drug of choice for management, and the crucial post-treatment follow-up needed to support those affected by this enigmatic disease.

1. What is Acute Flaccid Myelitis (AFM)?

Acute Flaccid Myelitis (AFM) is a neurological disorder that primarily affects the spinal cord, leading to sudden muscle weakness and paralysis. It belongs to a family of conditions known as acute flaccid paralysis (AFP) syndromes. AFM specifically targets the gray matter of the spinal cord, which contains nerve cells responsible for muscle movement. When these nerve cells become inflamed or damaged, it results in the hallmark symptoms of muscle weakness and flaccid paralysis.

The exact cause of AFM remains a subject of ongoing research, but it is often associated with enteroviruses, particularly Enterovirus D68 (EV-D68). Other viruses, such as West Nile virus and adenoviruses, have also been linked to AFM. While infections are a common trigger, not all individuals who contract these viruses will develop AFM, suggesting that genetic and environmental factors may play a role in its development.

2. How Common is Acute Flaccid Myelitis (AFM)?

AFM is considered a rare condition, but its prevalence has increased in recent years, prompting concern within the medical community. Since the first recognized outbreak in the United States in 2014, there have been periodic clusters of cases, typically occurring in late summer and fall.

The Centers for Disease Control and Prevention (CDC) in the United States tracks AFM cases and has reported varying numbers of cases annually. While the exact prevalence is difficult to determine due to underreporting and misdiagnosis, it is estimated that AFM affects approximately 1 in every 1 million people in the United States. However, this number may not account for all cases worldwide, and the true global prevalence remains unclear.

3. Who are the Doctors Who Treat Acute Flaccid Myelitis (AFM)?

The diagnosis and treatment of AFM require a multidisciplinary approach involving various medical specialists. The following healthcare professionals play crucial roles in the care of individuals with AFM:

  • a. Pediatricians and Neurologists: Pediatric neurologists often lead the diagnostic and treatment efforts for AFM cases, as the condition primarily affects children. Their expertise in pediatric neurology is essential in evaluating and managing AFM-related neurological symptoms.

  • b. Infectious Disease Specialists: In cases where AFM is triggered by viral infections, infectious disease specialists are consulted to identify the specific virus responsible and to guide treatment options.

  • c. Physical and Occupational Therapists: These therapists play a pivotal role in the rehabilitation process for individuals affected by AFM. They work to improve muscle strength, mobility, and functionality through tailored exercises and techniques.

  • d. Respiratory Therapists: For individuals with severe muscle weakness, respiratory therapists assist with managing respiratory function. This includes monitoring and providing mechanical ventilation if necessary.

  • e. Rehabilitation Specialists: Rehabilitation specialists, such as physiatrists, help create comprehensive rehabilitation plans tailored to the individual's needs, focusing on optimizing daily living skills and independence.

  • f. Social Workers and Psychologists: The psychological and emotional impact of AFM on both patients and their families cannot be overlooked. Social workers and psychologists provide emotional support and resources to help cope with the challenges posed by the condition.

4. What is the Drug of Choice for Acute Flaccid Myelitis (AFM)?

As of the last available information in September 2021, there is no specific antiviral drug approved for the treatment of AFM. Treatment primarily focuses on managing symptoms, providing supportive care, and addressing complications that may arise.

Supportive care may include:

  • - Pain management to alleviate discomfort associated with muscle weakness and paralysis.

  • - Physical and occupational therapy to improve muscle strength and mobility.

  • - Respiratory support for individuals with respiratory muscle weakness.

  • - Intravenous immunoglobulin (IVIG) therapy, which has been used in some cases to modulate the immune response.

It is essential to consult with a healthcare professional for the most up-to-date treatment recommendations, as research and clinical guidelines may have evolved since the time of writing.

5. What Post-Treatment Follow-Up is Needed?

The post-treatment phase of AFM management is crucial for achieving the best possible outcomes and providing ongoing support to affected individuals and their families. The following aspects should be considered in post-treatment follow-up:

  • a. Long-term Rehabilitation: Continuation of physical and occupational therapy is often necessary to maintain and improve muscle strength and functionality. A personalized rehabilitation plan should be developed and regularly assessed by healthcare providers.

  • b. Psychological Support: Coping with the physical and emotional challenges of AFM can be overwhelming. Access to mental health support, including counseling and support groups, can be beneficial for both patients and their families.

  • c. Ongoing Monitoring: Regular medical check-ups are essential to monitor the individual's overall health, assess any potential complications, and make adjustments to the treatment plan as needed.

  • d. Education: Providing education and resources to individuals and families is essential to empower them with knowledge about AFM, its management, and available support services.

  • e. Research Participation: Individuals and families may consider participating in clinical trials and research studies to advance our understanding of AFM and explore potential treatment options.


Acute Flaccid Myelitis (AFM) remains a rare and challenging neurological condition that primarily affects children. While its exact cause and treatment options continue to be subjects of ongoing research, a multidisciplinary approach involving pediatric neurologists, infectious disease specialists, therapists, and support professionals is essential for comprehensive care.

As we strive to unravel the mysteries surrounding AFM, ongoing education, awareness, and support are paramount. Through continued research and collaboration, we can hope to improve the lives of those affected by this enigmatic disease, offering them the best possible care and opportunities for recovery.

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